Gathering for their weekly knitting club at a small yarn shop on Manhattan's Upper West Side, a group of friends shares such challenges as raising children, navigating the ups and downs of their careers, and pursuing uncertain relationships.

Knit Two returns to the Manhattan knitting store Walker & Daughter five years after the death of the store's owner, Georgia Walker. Georgia's daughter Dakota runs the knitting store part-time with the help of the members of the Friday Night Knitting Club. Drawn together by their love for Dakota and the sense of family the club provides, each knitter is struggling with new challenges.