A strange new disease has a city in its grip, killing people with alarming speed. Two strangers are brought together in their urgent mission to find a cure. Dr. Tess Martin is a top virologist driven by her tragic past. Her only hope is Jack Bowen. Jack is a rule-breaking renegade who holds the key to the disease's horrendous origins.

A space shuttle burns up upon reentry causing debris to land across a wide area of the United States. Tucker Kaufman, a member of the CDC, visits one of the crash sites and gets a cut on his hand. Dr. Carol Bennell begins to notice that people are starting to act strange. She turns to her best friend, Dr. Ben Driscoll. He takes a small sample of the material to Dr. Stephen Galeano and they soon learn the substance is not from Earth. Carol's son, Oliver...