Troy (Steve Zahn), a troubled but well-intentioned father who has recently separated from his wife Sally (Jillian Bell). Aghast at Sally's refusal to let their trans son Joe (Sasha Knight) live as his authentic self, Troy runs off with Joe into the Montana wilderness. Meanwhile police detective (Ann Dowd) pursues them, but her resolve about the case is tested the more she learns about Joe's family.

Young soccer star Charlie has the world at his feet. With a top club desperate to sign him, his future is seemingly mapped out. But the teenager sees only a nightmare. Trapped in the body of a boy, Charlie is torn between wanting to live up to her father's expectations and shedding this ill-fitting skin. Charlie's next move will tear the family apart and threaten everything they hold dear.