Former Senator Selina Meyer was a charismatic leader and a rising star in her party with her eye on the White House, then she became Vice President. VEEP follows the whirlwind day-to day existence of Vice President Meyer as she puts out political fires, juggles a busy public schedule and demanding private life, and defends the President's interests, even as she tries to improve her dysfunctional relationship with the Chief Executive.

When D.C. reporter Cal McCaffrey is assigned to investigate the murder of an assistant to an up-and-coming politician, he uncovers a conspiracy that threatens to bring down the nation's power structures. In a town of spin-doctors and wealthy power brokers, he will discover one truth: when fortunes are at stake, no one's integrity, love, or life is safe.