Two young sisters spend a summer in the Japanese countryside with their father. The children's strange new home turns out to be a wonderland filled with creatures and a trio of furry woodland sprites who can only be seen by children.

Inflicted with a deadly curse, a young warrior named Ashitaka sets out to the forests of the west in search of the cure that will save his life. Once there, he becomes inextricably entangled in a bitter battle that matches Lady Eboshi and a proud clan of humans against the forest's animal gods ... who are led by the brave Princess Mononoke, a young woman raised by wolves.