A Boeing 777 arrives at JFK and is on its way across the tarmac, when it suddenly stops dead. All window shades are pulled down. All lights are out. All communication channels have gone quiet. Crews on the ground are lost for answers, but an alert goes out to the CDC. Dr. Eph Goodweather, head of their Canary project, a rapid-response team that investigates biological threats, gets the call and boards the plane. What he finds makes his blood run cold....

"It's been two years since the vampiric virus was unleashed in The Strain and the entire world now lies on the brink of annihilation. There has been a mass extermination of humans orchestrated by the Master-- an ancient vampire possessed of unparalleled powers. The future of humankind lies in the hands of a ragtag band of freedom fighters-- Dr. Eph Goodweather, Dr. Nora Martinez, Vasiliy Fet, and Mr. Quinlan, the half-breed offspring of the Master...