When a freak virus kills all but four passengers on an airplane at JFK, Ephraim Goodweather, head of the Center for Disease Control's "Canary Team, " is immediately called to the scene. With help from a mysterious Holocaust survivor, "Eph" and his colleague uncover the outbreak's ties to vampirism. Now, the only way to stop the terrifying disease from wiping out mankind is to face its source, a sinister supernatural creature known as "The Master."...

The war between the bloodthirsty strigoi and the remaining human survivors of New York intensifies in the chilling third season. Although Dr. Ephraim Goodweather's bioweapon initially helped stave off the vampiric creatures, they have evolved into a bigger threat to humanity than ever. Now, distraught over his kidnapped son, Eph teams with Dutch to search for signs of weakness in the strigoi.