"In an alchemical ritual gone wrong, Edward Elric lost his arm and his leg, and his brother Alphonse became nothing but a soul in a suit of armor. Equipped with mechanical "auto-mail" limbs, Edward becomes a state alchemist, seeking the one thing that can restore his and his brother's bodies ... the legendary Philosopher's Stone. Accompanied by their bodyguard, Alex Louis Armstrong, our heroes seek out their closest childhood friend, Winry Rockbell,...

When an alchemical ritual goes awry causing Edward Elric to lose limbs and his brother to become trapped in a suit of armor, Edward begins a quest to recover the one thing that can restore them, the legendary Philosopher's Stone.

Edward, Alphonse and Winry head south in search of Izumi Curtis, the master alchemist who taught the two brothers the art. An encounter with a pickpocket in Rush Valley starts them down a different path in search of an auto-mail blacksmith who Winry declares is the best he's ever seen.

The raid on the Devil's Nest becomes a slaughter, leaving Ed and Al forever affected by the battle. Foreign travelers, Mei and Ling, arrive from the country of Xing, searching for the Philosopher's Stone and a secret even the Elric brothers never imagined.

Ed, Al, and Winry return to Central Command only to be greeted with bad news. Lietuenant Colonel Maes Hughes has been murdered and the suspect is Second Lieutenant Maria Ross. Meanwhile, the living suit of armor bearing the soul of serial killer "Barry the Chopper" breaks out of jail and goes on a rampage. The mysterious Homunculi must come out of hiding to deal with the mess.

The political power structure of the military may be irreparable shattered when Colonel Mustang confronts Fuhrer President King Bradley with his suspicion that Bradley is a homunculus.

A homunculus manages to breach impenetrable Fort Briggs, and the Elric brothers discover a terrible alchemical secret that pervades every corner of the world as they know it. Meanwhile, Major Kimblee and a ruthless General Raven make Major General Olivier Mira Armstrong an offer she can't refuse. Whose side is she on, really? And how far is she willing to go?"

The brothers pursue fugitive May Chang to solve the mystery of why their alchemical powers were rendered inert while she and Scar continued to be able to wield them. Meanwhile, Scar enlists some unlikely help to delve into the secrets of his brother's alchemical knowledge. And the newest, most horrifying homunculus makes an appearance--!